No aerosol weapon, especially OC spray, stops a subject right in his or her tracks. It may take several seconds for the OC to take effect. This is especially the case with formulations designed to be used lower on your escalation-of-force scale that offer rapid decontamination. But even hotter formulations of OC won't work immediately on all subjects. Keep your distance, evaluate the spray's effects, and respond accordingly.
Always retain your ability to disengage and/or escalate. Knowing that nothing works all the time helps you plan for both success and failure. If the OC doesn't work, you must be ready to immediately respond with empty hand control tactics, disengage and get more distance, or draw either a baton or firearm in order to control the situation.
The best way to disengage is the tactical "L" concept. This maneuver allows an officer to disengage from a subject safely using his or her natural instinct. The natural response of anyone who is being attacked from the front is to unconsciously take a couple of steps backwards. This natural response is enhanced by then moving laterally four or five steps to change direction and confuse the assailant. The shape of the maneuver, an "L," gives this tactic its name.
Another key tactical concern is to avoid being sprayed by either blowback from your own OC, shots from another officer or even an OC assault from a subject. The best way to avoid being sprayed is to have a preplanned, practiced response developed prior to the assault. Some of the things you can do include holding your breath, covering your eyes with at least one arm, looking away momentarily to avoid the direct effects of the spray, having an empty hand strike ready for a counter strike, and being prepared to move and draw your firearm if it is not already out.
Your tactics should also include ways for multiple officers to take a suspect into custody. One very good way to do this is the "Circle of Defense" concept that was developed by Enforcement Technology Group as a part of its V-4 Control OC Spray Training Program.