More than 40 local and federal agencies are involved, and the National Football League has hired 4,000 private security personnel to assist those efforts, officials said.
Houston Police Chief Art Acevedo said the city has taken a slew of precautions to keep residents safe and warned that "johns" will be arrested as part of crackdown on human trafficking.
Despite the high-security presence, local law enforcement has encountered mostly petty thefts and counterfeiting, though police have rescued three women trafficking victims, he said.
With planned protests mounting in the coming days, Acevedo sent a message to outside protesters who may try to move into the city.
"We have a really long history of having really responsible activists in our community that have a long-standing relationship with the Houston Police Department," he said. "To those who might want to come in from outside to cause problems in Houston, know this: You'll be greatly outnumbered by activists that care about their message and don't want their protests ... to be hijacked by anyone coming to cause problems."
Though the Super Bowl requires a massive security presence, neither Houston PD nor the Harris County Sheriff's Office expects any reduction in services to the rest of the region.