VIDEO: FBI Arrests Wife of Orlando Nightclub Killer

The FBI on Monday arrested the wife of the gunman in the Orlando, FL, Pulse Nightclub massacre on charges connected to the shooting rampage, investigators confirmed to Fox News.

The June 2016 shooting, seen as the deadliest in modern U.S. history, killed 49 people and wounded dozens more. Police shot and killed gunman Omar Mateen after a three-hour standoff, during which he pledged allegiance to the Islamic State terror group.

The charges against his wife, 30-year-old Noor Salman, included aiding and abetting his attempts to support ISIS, as well as obstruction of justice.

FBI agents from the bureau's San Francisco field office picked up Salman outside her home in Rodeo, Calif., law enforcement sources said. She did not resist the arrest.

"Nothing can erase the pain we all feel about the senseless and brutal murders of 49 of our neighbors, friends, family members and loved ones. But today, there is some relief in knowing that someone will be held accountable for that horrific crime," Orlando Police Chief John Mina responded.

One of the officers who responded to the massacre, Master Sgt. Debra Clayton, was shot and killed last week outside a Walmart in the city. Her suspected killer, Markeith Loyd, remained on the loose one week later.